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Exchange 2010 send issue?

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Hi, I have deployed an Exchange server 2010 in the domain. OWA and Outlook work perfectly fine. iPhone and other internet mail clients (based on IMAP and SMTP) can receive and send emails from our local domain users (internally) but from other domains they only can receive not send. It goes to Outbox folder with the following error:

A copy has been placed in your Outbox. The recipient "user@domain.com" was rejected by the server because it does not allow relaying"

Please help me. Thanks.

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