Running Exchange 2010 SP2 no rollups. I have separate send connectors for some custom routing. Whenever I make an update to a send connector it takes up to 2 hours for the update to take effect. For example, if I remove a domain from a connector that routes through a smart host, it will be 2 hours before the mail stops routing through the smart host.
I see similar delays when I add IPs to my allowed relays receive connector.
I'm running 4 servers total, 2 mailbox (DAG), 2 CAS.